Design and analysis of drug combination experiments.
نویسندگان
چکیده
In this paper we present and discuss a novel, simple and easy to implement parametric modeling approach to assess synergy. An extended three parameter log-logistic model is used to analyse the data and calculate confidence intervals of the interaction indices. In addition the model corrects for the bias due to plate-location effects. The analysis is performed with PROC NLMIXED and SAS-code is provided. The approach is illustrated using data coming from an oncology study in which the inhibition effect of a combination of two compounds is studied using 96-well plates and a fixed-ratio design.
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عنوان ژورنال:
- Biometrical journal. Biometrische Zeitschrift
دوره 47 3 شماره
صفحات -
تاریخ انتشار 2005